World Science and Research PublishingGlobal Journal of Animal Scientific Research2345-43772420140816Serological Study on Mucosal Response of Cattle to Haemorrhagic Septicaemia Vaccine332336ENMortadaMohammed AbbakarYagoubMinistry of Agriculture Riyadh King Abdul Aziz Road P.O Box 11195 Saudi Arabia. mortada96@msn.comK.M.Suleiman201407162014081420140816The purpose of this study was to compare the efficacies of systemic immune response to mucosal vaccination against Pasteurella multocida infection in cattle. Three groups of ten cattle each were immunized subcutaneously and intranasally with bacterin of P. multocida serotype B: 2. Group 1 and Group 2 were immunized subcutaneously and intranasally with 0.5 ml of bacterin mixed with mucosal adjuvant respectively. Group 3 served as a control group was immunized subcutaneously with 1 ml of final vaccine product of bacterin as recommended dose according to Central Veterinary Research Laboratories, two cattle for each group unvaccinated control, all three groups received a booster dose on day 24 post inoculation.The level of the antibody immune response in these three groups was measured by the indirect haemagglutination test. Serum and nasal antibodies of vaccinated animals increased after the second vaccination, and this difference was statistically significant. Concentration of serum antibody against P. multocida increased from primary vaccination (6.25 antibody titer) on day 7 to (82.5 antibody titer) on day 31 after boosting animal, similar levels of protection were obtained from group 3. The nasal antibodies were rised from (3.75 antibody titer) at first vaccination on day 7 to (20 antibody titer) on day 31 after the second inoculation. The mucosal level of antibody in the intranasally vaccinated group was less compared to subcutaneously vaccinated group.