Association Between Socio-Demographic Factors and Adherence to Treatment by HIV Patients Undergoing Anti-Retroviral Treatment at The University of Calabar Teaching Hospital, Calabar, Nigeria

Paul Madukwe Ekperi, Wike Young Nyejirime, Uduonu Ekezie, Chinonye Peace

Abstract


Adherence has been shown to be a major predictor of viral suppression of HIV replication, emergence of ART drug resistance, disease progressions, and death. This study examined the association between demographic factors and adherence to treatment (clinic appointment and drug prescription) by HIV patients undergoing ART in University of Calabar Teaching Hospital, Calabar, Nigeria. The study further examined the reasons for non-adherence to treatment. A cross-sectional descriptive survey was adopted for the study and a structured questionnaire used to elicit information from four hundred respondents who fits into the inclusion criteria. Descriptive statistics such as frequencies, percentages and tables where used to analyze and present data collected on demographic characteristics. The association between respondents’ demographic characteristics and adherence to clinic appointment and prescribed drugs were analyzed inferentially using Pearson Chi-square test of association. Older HIV patients were found to adhere to clinic appointment and drug prescription than the younger patients. However, females were found to adhere to treatment more than the males. Furthermore, level of education was found to determine or influence adherence as HIV patients with formal education had higher adherence rate than those without formal education. Top on the list of the reasons for non-adherence to clinic appointment were distance, forgetfulness, cost of prescribed drugs, fear of been seen and religious beliefs. There is need for quality counseling for HIV patients undertaking ART to understand the implication of non-adherence. The government and health centers should give priority to improving adherence level to ART programme through free drug provision and constant follow up on HIV patients. Furthermore, the campaign against the stigmization of HIV patients should be intensified.

 


Keywords


Socio-demographic, Adherence, HIV patients, ART, UCTH

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References


A. O. Igwegbe, J. O. Ugboaja, and L. A. Nwajiaku, “Prevalence and determination of non-adherence to antiretroviral therapy among HIV positive pregnant women in Nnewi, Nigeria,” International Journal of Medicine and Medical Sciences, vol. 2, no. 8, pp. 238–245, 2010.

A. W. Nyambura, Factors that influence non-adherence to antiretroviral therapy among HIV/AIDS patients in central province, Kenya [Ph.D. thesis], 2009, http://www.who.int/hiv/.

Bangsberg DR, Perry S, Charlebois ED, Clark RA, Roberston M, Zolopa AR, et al. Non-adherence to highly active antiretroviral therapy predicts progression to AIDS. AIDS. 2001; 15:1181–3.

Berg MB, Safren SA, Mimiaga MJ, Grasso C, Boswell S, Mayer KH. Nonadherence to medical appointments is associated with increased plasma HIV RNA and decreased CD4 cell counts in a community-based HIV primary care clinic. AIDS Care. 2005;17:902–907.

Catz SL, McClure JB, Jones GN, Brantley PJ. Predictors of outpatient medical appointment attendance among persons with HIV. AIDS Care. 1999;11:361–373.

Charurat, M, Oyegunle, M, Benjamin, R, Habib, A, Eze, E, Ele, II, Ajayi, S, Eng, M & Mondal, P. 2010. Patient retention and adherence to antiretroviral in a large antiretroviral therapy program in Nigeria: a longitudinal analysis for risk factors. From: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868044 (accessed 25 March 2013).

Chesney MA. The elusive gold standard: future perspectives for HIV adherence assessment and intervention. J Acquir Immune Defic Syndr. 2006;43( Suppl 1):S3–S9.

Gill CJ, Hamer DH, Simon JL, Thea DM, Sabin LL. No room for complacency about adherence to antiretroviral therapy in sub-Saharan Africa. AIDS. 2005;19:1243–1249.

Idigbe EO, Adewole TA, Eisen G, et al. Management of HIV-1 infection with combination of Nevirapine, Stavudine, and Lamivudine; a preliminary report on the Nigerian antiretroviral program. J Acquir Immune Defic Syndr. 2005;40(1):65–69. 15.

Israelski D, Gore-Felton C, Power R, Wood MJ, Koopman C. Sociodemographic characteristics associated with medical appointment adherence among HIV-seropositive patients seeking treatment in a county outpatient facility. Preventive Medicine. 2001;33:470–475.

Kissinger P, Cohen D, Brandon W, Rice J, Morse A, Clark R. Compliance with Public-Sector Hiv Medical-Care. Journal of the National Medical Association. 1995;87(1):19–24.

Kitara and Aloyo (2012). HIV/AIDS Stigmatization, the Reason for Poor Access to HIV Counseling and Testing (HCT) Among the Youths in Gulu (Uganda) Afr. J. Infect. Dis. (2012) 6(1): 12 - 20

Lambo E. Nigeria has established 74 ARV treatment centers nationwide. HIV/AIDS News. 2006 March 15.

M. Carter, “Adherence. Information series for HIV positive people. NAM,” 2005, http://www.aidsmap.com/Adherence/cat/1464/.

Mills EJ, Nachega JB, Buchan I, et al. Adherence to antiretroviral therapy in sub-Saharan Africa and North America: A meta-analysis. JAMA. 2006; 296(6):679–690.

NACA (2017) ‘National Strategic Framework on HIV and AIDS: 2017 -2021’ [pdf

Nozaki, I, Dube, C, Kakimoto, K, Yamada, N & Simpungwee, JB. 2011. Social factors affecting ART adherence in rural settings in Zambia. From: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144480/ (accessed 14 December 2018)

Rotheram-Borus MJ, Murphy DA, Coleman CL, Kennedy M, Reid MH, Cline TR. Risk acts, health care, and medical adherence among HIV+ youths in care over time. AIDS and Behavior: 2012; 199;1:43–52.

Shumba, C, Atuhaire, R, Imakit, R, Atukunda, R & Memiah, P. 2013. Missed doses and missed appointments: adherence to ART among adult patients in Uganda. ISRN AIDS. Article ID 270914. From: http://www.hindawi.com/ism/aids/2013/270914/ref (accessed 15 March 2013).

UNAIDS (2005) Report on the global AIDS Epidemic. Available at: www.unaids.org Accessed January 15, 2019.

UNAIDS (2017) Data Book [pdf]

UNAIDS ‘AIDSinfo’ [Accessed October 2018]

Wanchu A, Kaur R, Bambery P, Singh S. Adherence to generic reverse transcriptase inhibitor-based antiretroviral medication at a Tertiary Center in North India. AIDS Behav. 2007;11:99–102.

WHO. World health statistics 2007. Geneva, Switzerland: World Health Organization; 2007


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